Furthermore, SOD1-null mice showed a reduced average islet size of 8,490 ± 685.5 μm 2 compared with 9,235 ± 1,541 μm 2 in WT animals, although this difference did not reach statistical significance ( Fig. 5 C ).
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Genetic disruption of SOD1 gene causes glucose intolerance and impairs β-cell function.
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