a trend towards significancep = 0.057
MiR-31 was also found differentially expressed with mean fold increase of 15 in DMD patients and showed a trend towards significance (p = 0.057).
MiR-31 was also found differentially expressed with mean fold increase of 15 in DMD patients and showed a trend towards significance (p = 0.057).
Our analysis detected a trend towards normalization of these miRNA between the pre- and post-treatment samples of the systemic trial, which however failed to reach statistical significance.
Our analysis in DMD patients did not identify a significant difference when the levels of dystromirs were compared in serum samples before treatment and in post-treatment samples taken at week 12, when the last dose of eteplirsen was administered, despite an encouraging trend for normalisation of the miRNAs.