Down-regulation of miR-126 is associated with colorectal cancer cells proliferation, migration and invasion by targeting IRS-1 via the AKT and ERK1/2 signaling pathways.

Although there was a decreasing trend in the IRS-1 mRNA expression level in cells transfected with miR-126 mimic, it did not reach statistical significance between the two groups tested ( P >0.05) ( Figure 3B ).

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