The effect of metformin on apoptosis in a breast cancer presurgical trial.

Interestingly, we found a highly significant positive correlation between KI67 LI and TUNEL levels both at baseline ( Figure 3 ) and surgery ( Figure 4 ) (Spearman's ρ =0.5 and 0.6, respectively, P <0.0001).

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When we considered the interaction between treatment and the HOMAi on TUNEL, we found a borderline significant trend to a different metformin effect according to the HOMAi ( P =0.1, Figure 2 ).

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