Similar to our previous report [ 12 , 21 ], at the end of 30 min LAD with 2 or 3 hours reperfusion, the myocardial IS between control and diabetic rats did not reach statistical significance, while the release of plasma CK-MB was significantly increased in D relative to C after reperfusion (Figure 1 B) ( P < 0.05), which was consistent with a significant increase of plasma LDH ( P < 0.05) and cardiac TNFα protein expression ( P < 0.05) after 30 min LAD occlusion with 2 or 3 hours reperfusion (Figure 1 C and D).
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Susceptibility to myocardial ischemia reperfusion injury at early stage of type 1 diabetes in rats.
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