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Immunization against active ghrelin using virus-like particles for obesity treatment.

Curr Pharm Des · 2013 · PMC3850261 · PMID 23859551

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Although vaccinated animals gained less weight when compared with control animals, this difference failed to reach statistical significance, which may be explained by the short follow-up time or the activation of compensatory mechanisms of energy homeostasis pathways.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.