Urinary paraben concentrations and ovarian aging among women from a fertility center.

In a sensitivity analysis controlling for age categorized into < 37 years and ≥ 37 years, the association between day-3 FSH and PP became stronger: The mean difference in day-3 FSH was 1.24 IU/L [95% confidence interval (CI): –0.18, 2.67] in tertile 3 [using age as a continuous covariate, the mean difference was 1.02 (95% CI: –0.40, 2.43)], and 1.19 IU/L (95% CI: –0.22, 2.60) in tertile 2 [using age as a continuous covariate, the mean difference was 1.16 (95% CI: –0.26, 2.57)], both compared with tertile 1 (with the p trend of 0.08 becoming borderline significant).

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We found a suggestive trend of lower AFC with increasing urinary PP tertiles [mean percent change (95% CI) for tertiles 2 and 3 compared with tertile 1, respectively, were –5.0% (–23.7, 18.4) and –16.3% (–30.8, 1.3); trend p -value ( p trend ) = 0.07] as well as higher day-3 FSH with higher urinary PP tertiles [mean change (95% CI) for tertiles 2 and 3 compared with tertile 1 were 1.16 IU/L (–0.26, 2.57) and 1.02 IU/L (–0.40, 2.43); p trend = 0.16].

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