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The urotensin system is up-regulated in the pre-hypertensive spontaneously hypertensive rat.

PLoS One · 2013 · PMC3855556 · PMID 24340095

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Urine flow and sodium excretion rates tended to fall during URP infusion in the SHR; however these changes did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.