Signatures of pleiotropy, economy and convergent evolution in a domain-resolved map of human-virus protein-protein interaction networks.

In contrast, the difference in enrichment for non-LMB domains between human proteins targeted by viruses and generic human proteins is only marginally significant (Fold enrichment = 0.96; P = 0.012; Figure 5 ), suggesting that the observed enrichment for LMB domains among human proteins targeted by viruses is not a simple result of superior domain annotation among these proteins.

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