Epigenetic regulation of depot-specific gene expression in adipose tissue.

PLoS One · 2013 · PMC3855576 · PMID 24340035

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highly significantno p-value reported

By combining both data sets, we identified a highly significant set of depot-specifically expressed genes that appear to be epigenetically regulated.

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a clear trendno p-value reported

Genes upregulated in abdominal tissue samples generally showed reduced methylation levels in regions close to the transcription start site (TSS200, 5 ́-UTR) and the first exon of genes ( Figure 2D ) whereas genes downregulated in abdominal cells showed a clear trend towards hypermethylation in these regions.

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