Interleukin-encoding adenoviral vectors as genetic adjuvant for vaccination against retroviral infection.

In addition, the spleens of mice co-immunized with these interleukins were also rather less enlarged than spleens of mice which received Ad.pIXgp70 alone, but this did not reach statistical significance.

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The difference in neutralizing activity was also apparent when neutralizing antibodies of IgG type were analyzed ( Figure 3B ), with an obvious trend to enhanced neutralizing IgG antibodies in mice that had received IL5, IL6, or IL23 vectors compared to Ad.pIXgp70 alone.

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