HER4 expression status correlates with improved outcome in both neoadjuvant and adjuvant Trastuzumab treated invasive breast carcinoma.

The correlation between HER4 H-Score and HER4 RT-qPCR was highly significant, with a correlation coefficient of r2= 0.85 (p<0.0001; CI: 0.80-0.94) for the neoadjuvant cohort (Figure 2A ) and r2= 0.75 (p<0.0001; CI: 0.44-0.84) for the metastatic cohort (Figure 2B ).

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patients that lacked HER4 over-expression (HER2-Pos and HER4-Neg); this difference did not reach statistical significance (p=0.47) (Figure 6B ).

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