nominally significantp < 0.05
Index SNPs in 19 of the 21 loci exhibited interactions with alcohol as evidenced by either a suggestive 1 df interaction test or a significant/suggestive joint 2 df test in conjunction with a nominally significant ( p < 0.05) 1 df interaction test; two PP loci (represented by rs4953404 and rs12292796) appeared to be driven by main effects only (1 df interaction tests have p -values > 0.3 as shown in Table 3 ) and will be excluded from further discussion (see Figures S8 – S14 for the regional association plots for all the significant and suggestive loci).