In 5 of 10 case–control studies and all prospective cohort studies that considered alcohol consumption, researchers found a positive trend with respect to dose response (see Cho et al. 2004 ).
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Thus, the analysis of eight pooled cohort studies showed a significant trend between increasing alcohol intake and the risk of colorectal cancer, with consumption of more than 45 g (or about three drinks) per day increasing the risk by 45 percent ( Cho et al. 2004 ).