Also a significant trend for plecanatide was achieved for weekly responder rate, median time to first SBM, stool consistency, straining, and PAQ-QoL scores. 63 Finally, elobixibat, an enantiomer of 1,5-benzothiazepine, acts locally in the lumen of the gastrointestinal tract, binding and inhibiting the ileal bile acid transporter, with enhanced delivery of bile acid to the colon.
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