MicroRNA-regulated non-viral vectors with improved tumor specificity in an orthotopic rat model of hepatocellular carcinoma.

Gene Ther · 2013 · PMC3864878 · PMID 23719066

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In striking contrast these same vectors did not result in significant repression of Fluc activity within the tumor (although 122 vector showed a trend towards decreased expression), indicating that vectors regulated by miR-122 and miR-26a can help attenuate off-target expression in the liver but maintain high expression levels in the tumor ( Figure 5C ).

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