Although the relative risk estimates for ER-PR- breast malignancies were in a similar direction to the ER+PR+ tumors and no statistical heterogeneity between the breast cancer subtypes was observed, it should be noted that risk associations for ER-PR- malignancies were weaker in magnitude and failed to reach statistical significance.
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Reproductive factors and risk of hormone receptor positive and negative breast cancer: a cohort study.
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The sentences
The risk associations of menarcheal age, and time period between menarche and first full-term childbirth with ER-PR-tumors were in the similar direction with risk of ER+PR+ tumors (p het = 0.50), although weaker in magnitude and statistically only borderline significant.