Pre-symptomatic activation of antioxidant responses and alterations in glucose and pyruvate metabolism in Niemann-Pick Type C1-deficient murine brain.

PLoS One · 2013 · PMC3867386 · PMID 24367541

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also found significantly decreased PDH protein levels and a strong trend to increased pyruvate levels in the cerebella of 1-week old Npc1 -/- mice [71] .

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.