Non-susceptibility to antibiotics did not change significantly (penicillins, cephalosporins, tetracyclines) when the increase in rate of antimicrobial prescribing was relatively small (less than 50% over the study period), while non-susceptibility to macrolides (use increase of 83%) increased significantly in non-AI/AN with a strong trend in AI/AN persons, and non-susceptibility to trimethoprim/sulfamethoxazole (150% increase in use) increased significantly in both AI/AN and non-AI/AN populations.
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Streptococcus pneumoniae non-susceptibility and outpatient antimicrobial prescribing rates at the Alaska Native Medical Center.
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