Antihyperalgesia by α2-GABAA receptors occurs via a genuine spinal action and does not involve supraspinal sites.

However, the difference between wild-type and hoxb8 - α 2 −/− mice did not reach statistical significance ( P =0.19) and effects of conditional deletion or mutation of the α 2 subunit were therefore not further investigated.

also in 111,027 other papers