The PI3-kinase delta inhibitor idelalisib (GS-1101) targets integrin-mediated adhesion of chronic lymphocytic leukemia (CLL) cell to endothelial and marrow stromal cells.

PLoS One · 2013 · PMC3871531 · PMID 24376763

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did not reach statistical significanceno p-value reported

Idelalisib also significantly reduced CLL cell adhesion to unstimulated 9-15c BMSC, but this idelalisib-induced reduction in adhesion of CLL cells to other unstimulated EC or BMSC layers was minor and did not reach statistical significance.

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