In our study population, courses conducted for patients carrying the AA genotype of rs1801131 ( MTHFR c.1298AA) tended to have a higher MTX concentration at 48 hrs; however, this association did not reach statistical significance.
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Polymorphisms of MTHFR Associated with Higher Relapse/Death Ratio and Delayed Weekly MTX Administration in Pediatric Lymphoid Malignancies.
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