TRC210258, a novel TGR5 agonist, reduces glycemic and dyslipidemic cardiovascular risk in animal models of diabesity.

Diabetes Metab Syndr Obes · 2013 · PMC3873233 · PMID 24379686

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Treatment with TRC210258 for 4 weeks in DIO mice also showed a trend toward amelioration of Homeostasis Model of Assessment-Insulin Resistance, an index of insulin resistance ( Figure 5D ).

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