Neuropilin-1 expression characterizes T follicular helper (Tfh) cells activated during B cell differentiation in human secondary lymphoid organs.

Nrp1 + Tfh cells also expressed more CXCL13 , more PDCD1 , and more IL21R than Nrp1 - Tfh cells, although these differences did not reach statistical significance ( Figure 6 B-C ).

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The difference in Nrp1 expression between PD-1 + ( Figure 1 D ) or ICOS hi ( Figure 1 F ) Tfh cells and PD-1 - or ICOS lo non-Tfh cells was highly significant once data from multiple donors was analyzed.

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