The X-ACT study compared capecitabine and iv 5-FU/LV Mayo clinic regimen in patients with resected Stage III disease, and showed a trend towards superiority of capecitabine in both DFS (HR 0.87, CI 0.75-1.0) and overall survival (HR 0.84, CI 0.69-1.01).[ 13 ] Oxaliplatin, irinotecan, and biological agents have shown benefit in the metastatic setting and were thus studied in the adjuvant setting.
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