In vivo monitoring of sorafenib therapy effects on experimental prostate carcinomas using dynamic contrast-enhanced MRI and macromolecular contrast media.

PS showed a highly significant inverse correlation with tumor cell apoptosis (TUNEL; r = −0.85, P < 0.001).

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Since proteins extravasate slowly, the build-up of concentration in the extravascular space is slow, and a long measurement time is required to identify a clear trend.

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