BAG-1 suppresses expression of the key regulatory cytokine transforming growth factor β (TGF-β1) in colorectal tumour cells.

Further, there was a highly significant increase in CFE when the NRK cells were treated with the HCT116/BAG-1 siRNA CM (p≤0.001, Figure 4C ) which again was blocked by pre-incubation with the blocking antibody.

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Of note, under basal conditions, reduction of BAG-1 levels by RNAi caused a small but reproducible induction of TGFB1 reporter activity although this failed to reach statistical significance.

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