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Activation of the Nrf2/HO-1 antioxidant pathway contributes to the protective effects of Lycium barbarum polysaccharides in the rodent retina after ischemia-reperfusion-induced damage.

PLoS One · 2014 · PMC3882254 · PMID 24400114

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However, I/R could induce an increase in the expression of HO-1 in the retina, although this increase failed to reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.