Patent ductus arteriosus in preterm infants: do we have the right answers?

There is no enough evidence to support the routine use of diuretics for prevention or treatment of congestive heart failure in HS-PDA, and a systematic review of the coadministration of furosemide in indomethacin-treated neonates showed a trend toward failure of ductal closure in furosemide-treated patients because furosemide increases prostaglandins production and could potentially decrease the ductal response to indomethacin [ 119 ].

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