Circulating and dietary omega-3 and omega-6 polyunsaturated fatty acids and incidence of CVD in the Multi-Ethnic Study of Atherosclerosis.

4 , 6 Indeed, we found a nonsignificant trend toward higher CVD risk with higher circulating LA, as also seen in older US adults. 32 Differences in food sources of ALA and LA may at least partly explain inconsistencies across prior studies.

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Cross‐Sectional Associations of Circulating n‐3 ALA and n‐6 PUFA With CVD Risk Factors Circulating ALA was positively associated with plasma triglycerides, inversely associated with LDL‐C, and CRP, and showed a trend toward higher plasma HDL‐C ( P trend =0.08; Table 4 ) and higher sTNF‐R1 ( P trend =0.08).

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