Fate of lymphocytes after withdrawal of tofacitinib treatment.

PLoS One · 2014 · PMC3887061 · PMID 24416411

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a slight trendno p-value reported

Only a slight trend toward a lower STAT5 phosphorylation was observed in PHA stimulated cells after Tofa treatment, while STAT6 phosphorylation didn't show appreciable changes.

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showed a trendno p-value reported

In contrast, the only STAT protein that showed a trend increase in phosphorylation after the second period of incubation was STAT3, suggesting a possible role of JAK1-STAT3 pathway in the proliferation rebound observed after withdrawal of the drug.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.