Although we observed no significant difference in the liver, there was a clear trend toward a decrease in phosphorylation levels of both AKT at the Ser473 site and insulin receptor substrate-1 (IRS1) at the Tyr612 site in WT-PM mice; however, these levels were increased in the CCR2-PM group ( Figure 5C ).
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Air pollution-mediated susceptibility to inflammation and insulin resistance: influence of CCR2 pathways in mice.
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