Challenges in optimizing chemoradiation in locally advanced non small-cell lung cancers in India.

Several NSCLC trials and meta-analysis have compared sequential and concomitant combinations directly, almost all of which showed a trend in favor of concomitant radiochemotherapy.[ 5 , 6 ] However, some authors still believe that more evidence is required to prove the superiority of concurrent chemoradiation due to heterogeneity of the included trials in the meta-analysis, low patient numbers and lack of statistical power.[ 7 ] Most of the data supporting this observation comes from the developed world and rarely have good-quality clinical trials been carried out in developing countries.

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