Lipid accumulation, lipid oxidation, and low plasma levels of acquired antibodies against oxidized lipids associate with degeneration and rupture of the intracranial aneurysm wall.

The association of IgG antibodies against OxLDL or malondialdehyde modified LDL with SAH was clear in females (median RLU for antibodies against OxLDL: 34 276 in unruptured sIA patients vs 25 127 in SAH patients, P < 0.006, Mann–Whitney U and median RLU for malondialdehyde modified LDL: 48 100 in unruptured sIA patients vs 34 490 in SAH patients, P < 0.001, Mann–Whitney U) but only a statistical trend in males (P = 0.067, 0.112) respectively, Mann–Whitney U).

also in 2,798 other papers

50%) but failed to reach statistical significance (n = 92).

also in 6,035 other papers

Acquired humoral immunity (IgG) against oxidized lipid epitopes associates with aneurysm rupture Plasma IgG antibodies against a modified peptide of the ApoB100 protein were found in 40/92 (43%) of the sIA patients, and had an increasing trend in SAH patients (33% vs. 50%) but failed to reach statistical significance (n = 92).

also in 63,971 other papers