Perturbation of human coronary artery endothelial cell redox state and NADPH generation by methylglyoxal.

When GSH levels were expressed as a percentage of the total pool ( Figure 2D ) there was a trend towards a more oxidising environment (less GSH, more GSSG) with increasing MGO (77±8% present as GSH in control cells; 69±7% with 500 μM MGO), however this did not reach statistical significance.

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