Differences in the average expression level of miR-29b and miR-26b among basal-like breast cancers exhibiting aberrant DNA hypermethylation versus those lacking aberrant DNA hypermethylation did not reach statistical significance ( Fig. 2A ), although there was a distinct trend towards lower expression in the basal-like breast with aberrant DNA hypermethylation (p=0.11 and p=0.08, respectively).
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Dysregulation of microRNA expression drives aberrant DNA hypermethylation in basal-like breast cancer.
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