Investigation of complement component C4 copy number variation in human longevity.

Those differences were not statistically significant (p = 0.14), but a significant trend was detected in our secondary endpoint analysis, when the sample was divided into four different age subgroups (≤45 years, 46–60 years, 61–79 years and >91 years, p = 0.03) ( Table 4 and Supplementary Table S5 in File S1 ).

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