Comparison of peak CE-specific responses in the 4 macaques before (2 weeks after vaccination 2) and after the heterologous boost (2 weeks after vaccination 3) showed that the p24CE DNA boost increased the pre-existing CE-specific T cell responses ( Figure 4B–D ), although the difference did not reach statistical significance.
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Altered response hierarchy and increased T-cell breadth upon HIV-1 conserved element DNA vaccination in macaques.
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