Intranasal vaccination promotes detrimental Th17-mediated immunity against influenza infection.

PLoS Pathog · 2014 · PMC3900655 · PMID 24465206

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In contrast, mice vaccinated via the footpad showed a trend towards higher serum antibody responses (8–32 fold) for all isotypes tested compared to mice inoculated via the intranasal route ( Figure 4B ).

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