Weight loss from baseline was greater in the vaccine than placebo group, evident beginning at Ch+2 and marginally significant across the full study period (% weight loss p = 0.048; absolute loss p = 0.06) ( Figure 3A ).
Lung Histopathology At Ch+5, animals sacrificed from the vaccine group had higher combined mean/median lung inflammatory scores than placebo animals (5.8/5.5 versus 2.1/2.0), a difference that did not reach statistical significance (p = 0.051) ( Table S9 ).
Consistent with lung virus findings, lung inflammation was also increased more than 2.5-fold in vaccinated compared to placebo animals at Ch+5 although with fewer animals sacrificed on that day the difference fell just short of statistical significance.