LSN2424100: a novel, potent orexin-2 receptor antagonist with selectivity over orexin-1 receptors and activity in an animal model predictive of antidepressant-like efficacy.

Front Neurosci · 2014 · PMC3904085 · PMID 24478625

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.0600

boldest claim

The sentences

did not reach statistical significancep > 0.05actually significant

(S)-Almorexant treatment in rats produced a significant increase in reinforcers received [ F (3, 30) = 4.09, p < 0.02; Figure 5A ], while the reduction in lever presses emitted did not reach statistical significance ( p > 0.05).

also in 111,027 other papers

did not quite reach statistical significancep = 0.06so close (0.05 < p ≤ 0.1)

The antidepressant-like effect of imipramine was maintained in mice lacking OX1 receptors, as demonstrated by a dose-dependent increase in reinforcers received up to 15 mg/kg [206% of control; F (3, 44) = 3.33, p = 0.028; Figure 3C ], and a decrease in lever presses emitted (63% of control) but this difference did not quite reach statistical significance [ F (3, 44) = 2.64, p = 0.06; Dunnett's post-hoc test, p = 0.02; Figure 3C ].

also in 679 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.