Inflammatory activation is associated with a reduced glucocorticoid receptor alpha/beta expression ratio in monocytes of inpatients with melancholic major depressive disorder.

Transl Psychiatry · 2014 · PMC3905228 · PMID 24424390

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did not reach statistical significanceno p-value reported

GRα and GRβ expression in monocytes and their relation with the expression of cluster 1 and cluster 2 inflammatory genes With regard to the GRα and GRβ expression, we found a significant downregulation of the active GRα in MDD patients (F (1,86) =11.99, P =0.001), whereas there was a trend for an upregulation of the inactive GRβ, that did not reach statistical significance.

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