Novel marker for the onset of frontotemporal dementia: early increase in activity-dependent neuroprotective protein (ADNP) in the face of Tau mutation.

3C ) showed a trend toward increased tau 4R expression (exon inclusion) in 2-month-old ADNP+/− mice compared to ADNP+/+ controls ( p <0.05, one tail, t-test comparing only tau 4R expression), which disappeared in older, 9-month-old mice, showing similar tau species expression in the ADNP+/+ and ADNP+/− mice ( Fig. 3C ).

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