Preservation and compensation: the functional neuroanatomy of insight and working memory in schizophrenia.

There was also a marginally significant main effect of Group [F(2,49) = 3.08, p = 0.055, pta 2 = 0.11] indicating lower performance accuracy in poor insight patients, compared to preserved insight patients [F(1,30) = 3.23, p = 0.08, pta 2 = 0.01] and healthy participants [F(1,32) = 6.70, p = 0.01, pta 2 = 0.17]; preserved insight patients did not differ from healthy participants [F(1,36) = 0.15, p = 0.70].

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Interestingly, the poor insight group, compared with the healthy group, also showed a trend towards greater activity (an uncorrected level of significance) in some regions but only during the 1-back condition, consistent with previous suggestions ( Manoach, 2003 ) that individuals with lower WM capacity require much greater neuronal activity to maintain performance at a lower WM load.

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