Intraperitoneal prophylaxis with CpG oligodeoxynucleotides protects neutropenic mice against intracerebral Escherichia coli K1 infection.

J Neuroinflammation · 2014 · PMC3906862 · PMID 24456653

Europe PMC DOI

hedged sentences

0.0730

closest p · 1.5× alpha

0.2000

boldest claim

The sentences

did not quite reach statistical significanceP = 0.073so close (0.05 < p ≤ 0.1)

The percentage of inflammatory monocytes (CD45 + CD11b + Ly6C high CCR2 + ) among CD45 + leukocytes was significantly higher in CpG-treated mice ( P = 0.035; Mann-Whitney U test) while the total number of inflammatory monocytes/animal did not quite reach statistical significance ( P = 0.073; Mann-Whitney U test).

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failed to reach statistical significanceP = 0.2not close (p > 0.1)

The protection conferred by a single ip dose of 100 μg CpG ODN was mild in immunocompetent animals and failed to reach statistical significance (Figure 1 E; P = 0.2; log-rank test; survival 14 days after infection was 60% (12/20) in CpG ODN group versus 45% (9/20) in the buffer group).

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