SIRT1 but not its increased expression is essential for lifespan extension in caloric-restricted mice.

Aging Cell · 2014 · PMC3907112 · PMID 23941528

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showed a trendno p-value reported

SIRT1 expression showed a trend of increase in CR compared with AL animals (Fig. 2 ), in agreement with the increase in SIRT1 protein levels reported for mice, rats, and humans (Baur et al ., 2012 ).

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