Massive withdrawal symptoms and affective vulnerability are associated with variants of the CHRNA4 gene in a subgroup of smokers.

Single marker association tests provided three nominally significant results: effect of rs6090378 on FTND score ( p = 0.013); and effects of rs3787138 and rs3787140 on MNWS score variance were significant but not robust enough for Bonferroni corrections ( p = 0.021; p = 0.026, respectively) ( Table S1 ).

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HapScore test with MNWS score resulted in a marginally significant model ( p global = 0.054).

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