Considering the carry-over effect might be significant without a wash-out period, this study was also excluded.
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Effect of marine-derived n-3 polyunsaturated fatty acids on C-reactive protein, interleukin 6 and tumor necrosis factor α: a meta-analysis.
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The significant linear relationship between duration and effect size demonstrated that marine-derived n-3 PUFAs supplementation also had a significant lowering effect on IL-6 in healthy subjects although the pooled effect size was only marginally significant.