In the prospective SPARC (Stroke Prevention: Assessment of Risk in a Community) and NOMAS (Northern Manhattan Study) studies, the higher incidence of cerebral events in patients with PFO/ASA in comparison with patients with stroke and normal structure of the interatrial septum did not reach statistical significance [ 5 , 14 ].
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Patent foramen ovale and cryptogenic stroke - a statistical or cause-and-effect relationship? A neurological point of view.
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