The inhibition of 2-arachidonoyl-glycerol (2-AG) biosynthesis, rather than enhancing striatal damage, protects striatal neurons from malonate-induced death: a potential role of cyclooxygenase-2-dependent metabolism of 2-AG.

33 The Nissl staining in the striatal parenchyma revealed some apparent reduction in the number of stained cells that did not reach statistical significance (see Figure 3d ), but the differences were evident and statistically significant in the case of GFAP immunostaining, which was higher in the malonate-lesioned animals treated with JZL184 (F(2,10)=41.22, P <0.0001; Figure 3c ), thus indicating stronger astrogliosis in the striatal parenchyma of these animals.

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